Article
Control of the negative IRES trans-acting factor KHSRP by ubiquitination.
Nucleic acids research - 9 Jan 2017
Kung Yu-An, Hung Chuan-Tien, Chien Kun-Yi, Shih Shin-Ru
Abstract excerpt
Cells and viruses can utilize internal ribosome entry sites (IRES) to drive translation when cap-dependent translation is inhibited by stress or viral factors. IRES trans-acting factors (ITAFs) are known to participate in such cap-independent translation, but there are gaps in the understanding as to how ITAFs, particularly negative ITAFs, regulate IRES-driven translation. This study found that Lys109, Lys121 and...
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