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Enterovirus 71 Infection Cleaves a Negative Regulator for Viral Internal Ribosomal Entry Site-Driven Translation

24 Jan 2013

Abstract excerpt

Far-upstream element-binding protein 2 (FBP2) is an internal ribosomal entry site (IRES) trans-acting factor (ITAF) that negatively regulates enterovirus 71 (EV71) translation. This study shows that EV71 infection cleaved FBP2. Live EV71 and the EV71 replicon (but not UV-inactivated virus particles) induced FBP2 cleavage, suggesting that viral replication results in FBP2 cleavage. The results also showed that...

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RNA and protein synthesis mechanisms
RNA regulation and disease
Viral Infections and Immunology Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23345520
DOI: 10.1128/jvi.02278-12

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