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Article

Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells

1 Nov 2016

Abstract excerpt

OBJECTIVE: The objective of this study was to investigate the mechanism of sensitivity to methotrexate (MTX) in human choriocarcinoma cells regarding DNA damage response. METHODS: Two choriocarcinoma cancer cell lines, JAR and JEG-3, were utilized in this study. An MTX-sensitive osteosarcoma cell line MG63, an MTX-resistant epithelial ovarian cancer cell line A2780 and an MTX-resistant cervical adenocarcinoma...

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PMID: 27895503
DOI: 10.2147/ott.s116387

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