Article
[Investigating genetic damage of workers occupationally exposed to methotrexate].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases - 1 Dec 2005
Deng Hong-ping, Zhang Yun-tao, He Ji-liang, Zhang Mei-bian, Jin Li-fen, Zheng Wei, Lou Jian-lin, Wang Bao-hong
Abstract excerpt
OBJECTIVE: To study genetic damage of workers alone occupationally exposed to methotrexate (MTX) with three end-points. METHODS: The blood samples from 21 workers exposed to MTX and 21 controls were detected with micronucleus test, comet assay, hprt gene mutation test and TCR gene mutation test. RESULTS: The mean micronuclei rate (MNR) and mean micronucleated cells rate (MCR) in 21 workers were 10.10 per thousand...
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