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Quantitative proteomic analysis identifies novel regulators of methotrexate resistance in choriocarcinoma

17 Jan 2020

Abstract excerpt

OBJECTIVE: Although methotrexate (MTX) is commonly used for the treatment of choriocarcinoma, chemoresistance to MTX may occur in a considerable fraction of patients. Further understanding on the mechanisms of MTX resistance would help to develop more effective therapy for choriocarcinoma. METHODS: Quantitative proteomic approach involving TMT labeling and LC-MS/MS was used to identify MTX resistance-related...

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PMID: 31955862
DOI: 10.1016/j.ygyno.2020.01.013

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