Article
Simulating Next-Generation Sequencing Datasets from Empirical Mutation and Sequencing Models.
PloS one - 1 Jan 2016
Stephens Zachary D, Hudson Matthew E, Mainzer Liudmila S, Taschuk Morgan, Weber Matthew R, Iyer Ravishankar K
Abstract excerpt
An obstacle to validating and benchmarking methods for genome analysis is that there are few reference datasets available for which the "ground truth" about the mutational landscape of the sample genome is known and fully validated. Additionally, the free and public availability of real human genome datasets is incompatible with the preservation of donor privacy. In order to better analyze and understand genomic...
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