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Article

The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease.

Nature immunology - 1 Jan 2017

Abdul-Sater Ali A, Edilova Maria I, Clouthier Derek L, Mbanwi Achire, Kremmer Elisabeth, Watts Tania H

Abstract excerpt

TRAF1 is a signaling adaptor known for its role in tumor necrosis factor receptor-induced cell survival. Here we show that monocytes from healthy human subjects with a rheumatoid arthritis-associated single-nucleotide polymorphism (SNP) in the TRAF1 gene express less TRAF1 protein but greater amounts of inflammatory cytokines in response to lipopolysaccharide (LPS). The TRAF1 MATH domain binds directly to three...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

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Share to TNF Receptor-Associated Factor 1

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Source

Identifiers

PMID: 27893701
DOI: 10.1038/ni.3618

Genes

TRAF1
SHARPIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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