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Article

Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia.

Bone - 1 Feb 2017

Boukpessi Tchilalo, Hoac Betty, Coyac Benjamin R, Leger Thibaut, Garcia Camille, Wicart Philippe, Whyte Michael P, Glorieux Francis H, Linglart Agnès, Chaussain Catherine, McKee Marc D

Abstract excerpt

Seven young patients with X-linked hypophosphatemia (XLH, having inactivating PHEX mutations) were discovered to accumulate osteopontin (OPN) at the sites of defective bone mineralization near osteocytes - the so-called hallmark periosteocytic (lacunar) "halos" of XLH. OPN was also localized in the pericanalicular matrix extending beyond the osteocyte lacunae, as well as in the hypomineralized matrix of tooth...

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Identifiers

PMID: 27884786
DOI: 10.1016/j.bone.2016.11.019

Genes

PHEX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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