Article
Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin.
The American journal of pathology - 1 Aug 2010
Boukpessi Tchilalo, Gaucher Celine, Léger Thibaut, Salmon Benjamin, Le Faouder Julie, Willig Cyril, Rowe Peter S, Garabédian Michèle, Meilhac Olivier, Chaussain Catherine
Abstract excerpt
Severe dental troubles are associated with X-linked hypophosphatemic rickets and are mainly related to impaired dentin mineralization. In dentin matrix, matrix extracellular phosphoglycoprotein (MEPE) may be protected from proteolysis by a specific interaction with PHEX (phosphate regulating gene with homologies to endopeptidases on the X chromosome). The objective of our work was to determine whether PHEX...
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