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Article

Defective Mineralization in X-Linked Hypophosphatemia Dental Pulp Cell Cultures.

Journal of dental research - 1 Feb 2018

Coyac B R, Hoac B, Chafey P, Falgayrac G, Slimani L, Rowe P S, Penel G, Linglart A, McKee M D, Chaussain C, Bardet C

Abstract excerpt

X-linked hypophosphatemia (XLH) is a skeletal disease caused by inactivating mutations in the PHEX gene. Mutated or absent PHEX protein/enzyme leads to a decreased serum phosphate level, which cause mineralization defects in the skeleton and teeth (osteomalacia/odontomalacia). It is not yet altogether clear whether these manifestations are caused solely by insufficient circulating phosphate availability for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to PHEX Phosphate Regulating Neutral Endopeptidase

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Source

Open in PubMed Open full text

Identifiers

PMID: 28880715
DOI: 10.1177/0022034517728497
PMCID: PMC6429567

Genes

PHEX
DMP1
MEPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defective Mineralization in X-Linked Hypophosphatemia Dental Pulp Cell Cultures.PMID 28880715Read ↗

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Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.Semantic proximity Read ↗

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