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Article

Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-β and tau pathology.

Alzheimer's research & therapy - 25 Nov 2016

Kehoe Patrick Gavin, Wong Steffenny, Al Mulhim Noura, Palmer Laura Elyse, Miners J Scott

Abstract excerpt

BACKGROUND: Hyperactivity of the classical axis of the renin-angiotensin system (RAS), mediated by angiotensin II (Ang II) activation of the angiotensin II type 1 receptor (AT1R), is implicated in the pathogenesis of Alzheimer's disease (AD). Angiotensin-converting enzyme-2 (ACE-2) degrades Ang II to angiotensin 1-7 (Ang (1-7)) and counter-regulates the classical axis of RAS. We have investigated the expression...

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Source

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Identifiers

PMID: 27884212
DOI: 10.1186/s13195-016-0217-7
PMCID: PMC5123239

Genes

ACE
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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