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Suppression of Adenovirus Replication by Cardiotonic Steroids

24 Nov 2016

Abstract excerpt

The dependence of adenovirus on the host pre-RNA splicing machinery for expression of its complete genome potentially makes it vulnerable to modulators of RNA splicing, such as digoxin and digitoxin. Both drugs reduced the yields of four human adenoviruses (HAdV-A31, -B35, and -C5 and a species D conjunctivitis isolate) by at least 2 to 3 logs by affecting one or more steps needed for genome replication....

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Identifiers

PMID: 27881644
DOI: 10.1128/jvi.01623-16

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