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Article

Digoxin Suppresses HIV-1 Replication by Altering Viral RNA Processing

28 Mar 2013

Abstract excerpt

To develop new approaches to control HIV-1 replication, we examined the capacity of recently described small molecular modulators of RNA splicing for their effects on viral RNA metabolism. Of the drugs tested, digoxin was found to induce a dramatic inhibition of HIV-1 structural protein synthesis, a response due, in part, to reduced accumulation of the corresponding viral mRNAs. In addition, digoxin altered viral...

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PMID: 23555254
DOI: 10.1371/journal.ppat.1003241

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