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Article

The conserved cellular roles of CLN proteins: Novel insights from Dictyostelium discoideum.

European journal of cell biology - 1 Jun 2023

Remtulla Adam A N, Huber Robert J

Abstract excerpt

The neuronal ceroid lipofuscinoses (NCLs), collectively referred to as Batten disease, are a group of fatal neurodegenerative disorders that primarily affect children. The etiology of Batten disease is linked to mutations in 13 genes that encode distinct CLN proteins, whose functions have yet to be fully elucidated. The social amoeba Dictyostelium discoideum has been adopted as an efficient and powerful model...

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PMID: 36917916
DOI: 10.1016/j.ejcb.2023.151305

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