Article
Nfix Induces a Switch in Sox6 Transcriptional Activity to Regulate MyHC-I Expression in Fetal Muscle.
Cell reports - 22 Nov 2016
Taglietti Valentina, Maroli Giovanni, Cermenati Solei, Monteverde Stefania, Ferrante Andrea, Rossi Giuliana, Cossu Giulio, Beltrame Monica, Messina Graziella
Abstract excerpt
Sox6 belongs to the Sox gene family and plays a pivotal role in fiber type differentiation, suppressing transcription of slow-fiber-specific genes during fetal development. Here, we show that Sox6 plays opposite roles in MyHC-I regulation, acting as a positive and negative regulator of MyHC-I expression during embryonic and fetal myogenesis, respectively. During embryonic myogenesis, Sox6 positively regulates...
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