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Article

Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo.

EMBO reports - 1 Jul 2008

von Hofsten Jonas, Elworthy Stone, Gilchrist Michael J, Smith James C, Wardle Fiona C, Ingham Philip W

Abstract excerpt

The zebrafish u-boot (ubo) gene encodes the transcription factor Prdm1, which is essential for the specification of the primary slow-twitch muscle fibres that derive from adaxial cells. Here, we show that Prdm1 functions by acting as a transcriptional repressor and that slow-twitch-specific muscle gene expression is activated by Prdm1-mediated repression of the transcriptional repressor Sox6. Genes encoding...

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Source

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Identifiers

PMID: 18535625
DOI: 10.1038/embor.2008.73
PMCID: PMC2424280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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