Article
Worldwide prevalence of PI3K-AKT-mTOR pathway mutations in head and neck cancer: A systematic review and meta-analysis.
Critical reviews in oncology/hematology - 1 Apr 2021
Moura Adriana Castelo de, Assad Daniele Xavier, Amorim Dos Santos Juliana, Porto de Toledo Isabela, Barra Gustavo Barcelos, Castilho Rogerio Moraes, Squarize Cristiane Helena, Guerra Eliete Neves Silva
Abstract excerpt
A systematic review (SR) and meta-analysis were conducted to determine the prevalence of PI3K-AKT-mTOR signaling pathway mutations in patients with head and neck cancer (HNC). Overall, 105 studies comprising 8630 patients and 1306 mutations were selected. The estimated mutations prevalence was 13 % for PIK3CA (95 % confidence interval [CI] = 11-14; I2 = 82 %; p < 0.0001), 4% for PTEN (95 % CI = 3-5; I2 = 55 %; p...
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