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Unlocking sperm chromatin at fertilization requires a dedicated egg thioredoxin in Drosophila

23 Nov 2016

Abstract excerpt

In most animals, the extreme compaction of sperm DNA is achieved after the massive replacement of histones with sperm nuclear basic proteins (SNBPs), such as protamines. In some species, the ultracompact sperm chromatin is stabilized by a network of disulfide bonds connecting cysteine residues present in SNBPs. Studies in mammals have established that the reduction of these disulfide crosslinks at fertilization...

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PMID: 27876811
DOI: 10.1038/ncomms13539

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