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Article

Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression.

EBioMedicine - 1 Dec 2016

Zeng Yanni, Navarro Pau, Xia Charley, Amador Carmen, Fernandez-Pujals Ana M, Thomson Pippa A, Campbell Archie, Nagy Reka, Clarke Toni-Kim, Hafferty Jonathan D, Smith Blair H, Hocking Lynne J, Padmanabhan Sandosh, Hayward Caroline, MacIntyre Donald J, Porteous David J, Haley Chris S, McIntosh Andrew M

Abstract excerpt

BACKGROUND: Both genetic and environmental factors contribute to risk of depression, but estimates of their relative contributions are limited. Commonalities between clinically-assessed major depressive disorder (MDD) and self-declared depression (SDD) are also unclear. METHODS: Using data from a large Scottish family-based cohort (GS:SFHS, N=19,994), we estimated the genetic and environmental variance components...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 27838479
DOI: 10.1016/j.ebiom.2016.11.003
PMCID: PMC5161419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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