Article
Prediction of genetic subgroups in adult supra tentorial gliomas by pre- and intraoperative parameters.
Journal of neuro-oncology - 1 Jan 2017
Nakae Shunsuke, Murayama Kazuhiro, Sasaki Hikaru, Kumon Masanobu, Nishiyama Yuya, Ohba Shigeo, Adachi Kazuhide, Nagahisa Shinya, Hayashi Takuro, Inamasu Joji, Abe Masato, Hasegawa Mitsuhiro, Hirose Yuichi
Abstract excerpt
Recent progress in neuro-oncology has validated the significance of genetic diagnosis in gliomas. We previously investigated IDH1/2 and TP53 mutations via Sanger sequencing for adult supratentorial gliomas and reported that PCR-based sequence analysis classified gliomas into three genetic subgroups that have a strong association with patient prognosis: IDH mutant gliomas without TP53 mutations, IDH and TP53...
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