Article
Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors.
Proceedings of the National Academy of Sciences of the United States of America - 29 Nov 2016
Danilova Ludmila, Wang Hao, Sunshine Joel, Kaunitz Genevieve J, Cottrell Tricia R, Xu Haiying, Esandrio Jessica, Anders Robert A, Cope Leslie, Pardoll Drew M, Drake Charles G, Taube Janis M
Abstract excerpt
Programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint blockade has led to remarkable and durable objective responses in a number of different tumor types. A better understanding of factors associated with the PD-1/PD-L axis expression is desirable, as it informs their potential role as prognostic and predictive biomarkers and may suggest rational treatment combinations. In the...
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