Article
CD274 Alterations and PD-L1 Expression on Tumor Cells and Tumor-Infiltrating Lymphocytes in Patients With Melanoma: Relationships to Histopathologic Features and Outcomes.
Archives of pathology & laboratory medicine - 9 Feb 2025
Irfan Aneeza, Khazaeli Mahyar, Milton Denái R, Nagarajan Priyadharsini, Cho Woo Cheal, Lenskaya Volha, Curry Jonathan L, Torres-Cabala Carlos A, Prieto Victor G, Wong Michael K K, Yang Richard K, Aung Phyu P
Abstract excerpt
Context.—: In patients with melanoma, the predictive and prognostic relevance of programmed death ligand 1 (PD-L1) protein expression on tumor cells and tumor-infiltrating lymphocytes (TILs) and of alterations in the gene encoding PD-L1, CD274, are not yet established. Objective.—: To address these gaps in knowledge. Design.—: We retrospectively evaluated 64 patients with melanoma treated with immune checkpoint...
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