Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers.

doi:10.1158/1535-7163.MCT-17-0386

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers.

Molecular cancer therapeutics - 1 Nov 2017

Goodman Aaron M, Kato Shumei, Bazhenova Lyudmila, Patel Sandip P, Frampton Garrett M, Miller Vincent, Stephens Philip J, Daniels Gregory A, Kurzrock Razelle

Abstract excerpt

Immunotherapy induces durable responses in a subset of patients with cancer. High tumor mutational burden (TMB) may be a response biomarker for PD-1/PD-L1 blockade in tumors such as melanoma and non-small cell lung cancer (NSCLC). Our aim was to examine the relationship between TMB and outcome in diverse cancers treated with various immunotherapies. We reviewed data on 1,638 patients who had undergone...

Topics

Aged
Animals
Antibodies, Monoclonal
B7-H1 Antigen
CTLA-4 Antigen
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Disease-Free Survival
Female
Humans
Immunotherapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Melanoma

Mice

Middle Aged

Mutation

Programmed Cell Death 1 Receptor

Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 28835386
DOI: 10.1158/1535-7163.MCT-17-0386
PMCID: PMC5670009

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers.PMID 28835386Read ↗

High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse CancersSemantic proximity Read ↗

Assessment of Tumor Mutational Burden and Outcomes in Patients With Diverse Advanced Cancers Treated With Immunotherapy.Semantic proximity Read ↗

Choosing tumor mutational burden wisely for immunotherapy: A hard road to explore.Semantic proximity Read ↗

Tumor Mutational Burden as a Predictor of Immunotherapy Response: Is More Always Better?Semantic proximity Read ↗

The Efficacy of Tumor Mutation Burden as a Biomarker of Response to Immune Checkpoint Inhibitors.Semantic proximity Read ↗

Tumor mutational burden for the prediction of PD-(L)1 blockade efficacy in cancer: challenges and opportunities.Semantic proximity Read ↗

Evaluating Tumour Mutational Burden as a Key Biomarker in Personalized Cancer Immunotherapy: A Pan-Cancer ApproachSemantic proximity Read ↗

The association between tumor mutational burden and prognosis is dependent on treatment context.Semantic proximity Read ↗

The Impact of TMB on Immunotherapy Protocols: A Comprehensive Analysis of Four Major CancersSemantic proximity Read ↗

Tumor mutational load predicts survival after immunotherapy across multiple cancer typesSemantic proximity Read ↗

Targeted literature review on use of tumor mutational burden status and programmed cell death ligand 1 expression to predict outcomes of checkpoint inhibitor treatment.Semantic proximity Read ↗

Association of High Tumor Mutation Burden in Non-Small Cell Lung Cancers With Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.