Article
Interaction Between PNPLA3 and SIRT5 Genetic Variants in Association with Liver Fibrosis Severity in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease.
Genes - 24 Oct 2024
Moonlisarn Kamonchanok, Somnark Pornjira, Boonkaew Bootsakorn, Bunchorntavakul Chalermarat, Tangkijvanich Pisit
Abstract excerpt
BACKGROUND/OBJECTIVES: This study evaluated the association between polymorphisms in the PNPLA3, TM6SF2, HSD17B13, and SIRT5 genes and the severity of fibrosis and steatosis in metabolic dysfunction-associated steatotic liver disease (MASLD). METHODS: Fibrosis and steatosis were assessed by MRE and MRI-PDFF, respectively. The polymorphisms were determined by allelic discrimination in blood samples. RESULTS: 204...
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