Article
Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model.
Oncotarget - 27 Dec 2016
Kawaguchi Kei, Igarashi Kentaro, Murakami Takashi, Chmielowski Bartosz, Kiyuna Tasuku, Zhao Ming, Zhang Yong, Singh Arun, Unno Michiaki, Nelson Scott D, Russell Tara A, Dry Sarah M, Li Yunfeng, Eilber Fritz C, Hoffman Robert M
Abstract excerpt
Melanoma is a recalcitrant disease in need of transformative therapuetics. The present study used a patient-derived orthotopic xenograft (PDOX) nude-mouse model of melanoma with a BRAF-V600E mutation to determine the efficacy of temozolomide (TEM) combined with tumor-targeting Salmonella typhimurium A1-R. A melanoma obtained from the right chest wall of a patient was grown orthotopically in the right chest wall...
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