Article
Tumor-Targeting Salmonella typhimurium A1-R Sensitizes Melanoma With a BRAF-V600E Mutation to Vemurafenib in a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model.
Journal of cellular biochemistry - 1 Aug 2017
Kawaguchi Kei, Igarashi Kentaro, Murakami Takashi, Zhao Ming, Zhang Yong, Chmielowski Bartosz, Kiyuna Tasuku, Nelson Scott D, Russell Tara A, Dry Sarah M, Li Yunfeng, Unno Michiaki, Eilber Fritz C, Hoffman Robert M
Abstract excerpt
Previously, a BRAF-V600E-mutant melanoma obtained from the right chest wall of a patient was grown orthotopically in the right chest wall of nude mice to establish a patient-derived orthotopic xenograft (PDOX) model. Trametinib (TRA), an MEK inhibitor, caused tumor regression. In contrast, another MEK inhibitor, cobimetinib (COB) could slow but not arrest growth or cause regression of the melanoma PDOX....
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