Article
Correlation between insulin-induced estrogen receptor methylation and atherosclerosis.
Cardiovascular diabetology - 10 Nov 2016
Min Jia, Weitian Zhong, Peng Cai, Yan Peng, Bo Zhang, Yan Wang, Yun Bai, Xukai Wang
Abstract excerpt
BACKGROUND: Hyperinsulinemia and insulin resistance have been recently recognized as an important cause of atherosclerosis. Clinical studies have also found that expression of the estrogen receptor is closely related to the incidence of atherosclerosis. This study investigate the effects of insulin and estrogen receptor α (ER-α) in atherosclerosis. METHODS: Double knockout ApoE/Lepr mice were given...
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