Article
[Correlation of polymorphisms of UDP-glucuronosyltransferase 1A7 gene to genetic susceptibility of lung cancer].
Ai zheng = Aizheng = Chinese journal of cancer - 1 Sept 2005
Feng Fei-Yue, Liang Gang, Lu Wen-Fu, Miao Xiao-Ping, Yu Chun-Yuan, Tan Wen, Zhou Yi-Feng, Sun Tong, Kang Bin, Zhou Tong, Pan Kai-Feng, Zhang Lian, Lin Dong-Xin
Abstract excerpt
BACKGROUND & OBJECTIVE: UDP-glucuronosyltransferase 1A7 (UGT1A7) plays an important role in detoxification through catalyzing combination of glucuronic acid and tobacco carcinogens, including benzo [alpha] pyrene, nitrosamine, and heterocyclic amine PhIP, therefore, inactivates the carcinogens. This study was to examine the correlation of polymorphisms of UGT1A7 gene to genetic susceptibility of lung cancer....
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