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Article

Assessment of the influence of Fc-γ receptor polymorphisms on biologics' pharmacokinetics in Tunisian rheumatoid arthritis patients.

British journal of clinical pharmacology - 1 Jun 2023

Mahmoud Ines, Moalla Myriam, Ben Tekaya Aicha, Charfi Rim, Rouached Leila, Bouden Selma, Tekaya Rawdha, Saidane Olfa, Abdelmoula Leila, Sfar Imen

Abstract excerpt

AIMS: This study aims to determine whether a modification in Fc-γ receptors' (FcgRs) affinity to Fc portion, caused by single nucleotide polymorphisms such as rs1801274-R131H FcgRIIa, rs396991-F158V FcgRIIIa and NA1/NA2-FcgRIIIb, might impact clearance of therapeutic monoclonal antibodies and thus serum drug levels and the development of anti-drug antibodies. METHODS: A cross sectional, multicentral and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36609675
DOI: 10.1111/bcp.15658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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