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Article

Identification of HLA-DRB1 association to adalimumab immunogenicity.

PloS one - 1 Jan 2018

Liu Mohan, Degner Jacob, Davis Justin Wade, Idler Kenneth B, Nader Ahmed, Mostafa Nael M, Waring Jeffrey F

Abstract excerpt

Anti-drug antibody formation occurs with most biological agents across disease states, but the mechanism by which they are formed is unknown. The formation of anti-drug antibodies to adalimumab (AAA) may decrease its therapeutic effects in some patients. HLA alleles have been reported to be associated with autoantibody formation against interferons and other TNF inhibitors, but not adalimumab. We analyzed samples...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29614084
DOI: 10.1371/journal.pone.0195325
PMCID: PMC5882140

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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