Article
CYP24A1-deficiency does not affect bone regeneration in distraction osteogenesis.
The Journal of steroid biochemistry and molecular biology - 1 Oct 2017
Husseini Abdallah, St-Arnaud René
Abstract excerpt
The putative biological activity of 24,25-(OH)2D remains unclear. Previous studies showed an increase in the circulating levels of this metabolite following fracture in chicks. Our laboratory has generated a mouse model deficient for the Cyp24a1 gene for studying the role of 24,25-(OH)2D. We set out to study the role of CYP24A1 and 24,25-(OH)2D in intramembranous bone formation during distraction osteogenesis in...
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