Article
Ankyrin-3 as a molecular marker of early-life stress and vulnerability to psychiatric disorders.
Translational psychiatry - 8 Nov 2016
Luoni A, Massart R, Nieratschker V, Nemoda Z, Blasi G, Gilles M, Witt S H, Suderman M J, Suomi S J, Porcelli A, Rizzo G, Fazio L, Torretta S, Rampino A, Berry A, Gass P, Cirulli F, Rietschel M, Bertolino A, Deuschle M, Szyf M, Riva M A
Abstract excerpt
Exposure to early-life stress (ELS) may heighten the risk for psychopathology at adulthood. Here, in order to identify common genes that may keep the memory of ELS through changes in their methylation status, we intersected methylome analyses performed in different tissues and time points in rats, non-human primates and humans, all characterized by ELS. We identified Ankyrin-3 (Ank3), a scaffolding protein with a...
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