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Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations

10 Jan 2025

Abstract excerpt

Prenatal maternal stress (PNMS) determines lifetime mental and physical health. Here, we show in rats that PNMS has consequences for placental function and fetal brain development across four generations (F0-F3). Using a systems biology approach, comprehensive DNA methylation (DNAm), miRNA, and mRNA profiling revealed a moderate impact of PNMS in the F1 generation, but drastic changes in F2 and F3 generations,...

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PMID: 39794497
DOI: 10.1038/s42003-024-07444-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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