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Article

The lasting impact of early-life adversity on individuals and their descendants: potential mechanisms and hope for intervention.

Genes, brain, and behavior - 1 Jan 2016

Cowan C S M, Callaghan B L, Kan J M, Richardson R

Abstract excerpt

The adverse effects of early-life stress are pervasive, with well-established mental and physical health consequences for exposed individuals. The impact of early adverse experiences is also highly persistent, with documented increases in risk for mental illness across the life span that are accompanied by stable alterations in neural function and hormonal responses to stress. Here, we review some of these...

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PMID: 26482536
DOI: 10.1111/gbb.12263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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