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Article

FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men.

PloS one - 1 Jan 2016

Kamura Yutaka, Iwata Minoru, Maeda Shiro, Shinmura Satomi, Koshimizu Yukiko, Honoki Hisae, Fukuda Kazuhito, Ishiki Manabu, Usui Isao, Fukushima Yasuo, Takano Atsuko, Kato Hiromi, Murakami Shihou, Higuchi Kiyohiro, Kobashi Chikaaki, Tobe Kazuyuki

Abstract excerpt

AIM: Several studies have demonstrated that polymorphisms within the fat-mass and obesity-associated gene (FTO) are associated with type 2 diabetes (T2D). However, whether the effects of the FTO locus on T2D susceptibility are independent of fat-mass increases remains controversial. To investigate this issue, we examined the association of FTO variants with T2D and various aspects of BMI history during adult life...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 27820839
DOI: 10.1371/journal.pone.0165523
PMCID: PMC5098825

Genes

FTO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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