Article
Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese.
BMC genetics - 22 Sept 2013
Qian Yun, Liu Sijun, Lu Feng, Li Huizhang, Dong Meihua, Lin Yudi, Du Jiangbo, Lin Yuan, Gong Jianhang, Jin Guangfu, Dai Juncheng, Hu Zhibin, Shen Hongbing
Abstract excerpt
BACKGROUND: Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans. But this association was abolished after adjustment for body mass index (BMI), suggesting that the effect of rs8050136 on T2D risk might be mediated by BMI in Europeans. However, the findings in subsequent...
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