Article
Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner.
Oncogene - 27 Apr 2017
Guo J-Y, Hsu H-S, Tyan S-W, Li F-Y, Shew J-Y, Lee W-H, Chen J-Y
Abstract excerpt
Tumor microenvironment (TME) plays an active role in promoting tumor progression. To further understand the communication between TME and tumor cells, this study aimed at investigating the involvement of CD44, a type I cell surface receptor, in the crosstalk between tumor cells and TME. We have previously shown that chondroitin sulfate proteoglycan serglycin (SRGN), a CD44-interacting factor, was preferentially...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.