Article
Impact of neonatal iron deficiency on hippocampal DNA methylation and gene transcription in a porcine biomedical model of cognitive development.
BMC genomics - 3 Nov 2016
Schachtschneider Kyle M, Liu Yingkai, Rund Laurie A, Madsen Ole, Johnson Rodney W, Groenen Martien A M, Schook Lawrence B
Abstract excerpt
BACKGROUND: Iron deficiency is a common childhood micronutrient deficiency that results in altered hippocampal function and cognitive disorders. However, little is known about the mechanisms through which neonatal iron deficiency results in long lasting alterations in hippocampal gene expression and function. DNA methylation is an epigenetic mark involved in gene regulation and altered by environmental factors....
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