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Article

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses

3 Nov 2016

Abstract excerpt

Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing...

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PMID: 27807231
DOI: 10.1128/jvi.00720-16

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