Article

Development of a Recombinant Single-Cycle Influenza Viral Vector as an Intranasal Vaccine against SARS-CoV-2 and SARS-like Betacoronaviruses

2025-12-01

Abstract excerpt

The COVID-19 pandemic has demonstrated the detrimental potential of zoonotic coronavirus transmission to human populations. Effective vaccines capable of eliciting immunity to SARS-CoV-2 have been pivotal in mitigating the spread of the virus. In this study, we describe the generation of a non-replicating pseudotyped influenza A virus (S-FLU), where the native haemagglutinin (HA) sequence is replaced with the codi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 31e93b5c-83f6-563b-b99e-2649a65f172a
DOI: 10.1101/2025.11.28.691177

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of a Recombinant Single-Cycle Influenza Viral Vector as an Intranasal Vaccine against SARS-CoV-2 and SARS-like BetacoronavirusesDOI 10.1101/2025.11.28.691177Read

Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in MiceSemantic proximity Read

Attenuated influenza virions expressing the SARS-CoV-2 receptor-binding domain induce neutralizing antibodies in miceSemantic proximity Read

Evolving SARS-CoV-2 Vaccines: From Current Solutions to Broad-Spectrum ProtectionSemantic proximity Read

Influenza viral particles harboring the SARS-CoV-2 spike RBD as a combination respiratory disease vaccineSemantic proximity Read

An intranasal vaccine durably protects against SARS-CoV-2 variants in miceSemantic proximity Read

Immunization with recombinant accessory protein-deficient SARS-CoV-2 protects against lethal challenge and viral transmissionSemantic proximity Read

Single-Dose Intranasal Immunisation with Novel Chimeric H1N1 Expressing the Receptor-Binding Domain of SARS-CoV-2 Induces Robust Mucosal Immunity, Tissue-Resident Memory T Cells, and Heterologous Protection in MiceSemantic proximity Read

Development and Characterization of Recombinant Vesicular Stomatitis Virus (rVSV)-based Bivalent Vaccine Against COVID-19 Delta Variant and Influenza VirusSemantic proximity Read

An intranasal influenza virus-vectored vaccine blocks SARS-CoV-2 replication in respiratory tissues of mice and hamstersSemantic proximity Read

Enhanced Protection from SARS-CoV-2 Variants by MVA-Based Vaccines Expressing Matched or Mismatched S Proteins Administered Intranasally to hACE2 MiceSemantic proximity Read

Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamstersSemantic proximity Read

Single-dose respiratory mucosal delivery of next-generation viral-vectored COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2Semantic proximity Read