B-cell activation and lymphoma in patients with HIV.

doi:10.1097/00001622-200209000-00009

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Article

B-cell activation and lymphoma in patients with HIV.

Current opinion in oncology - 1 Sept 2002

Martínez-Maza Otoniel, Breen Elizabeth Crabb

Abstract excerpt

The risk of developing non-Hodgkin lymphoma (AIDS lymphoma) is greatly increased in HIV infection. Disruption of immune function by HIV infection may contribute to lymphomagenesis by inducing (1) loss of immunoregulation of Epstein-Barr virus-infected B cells [immunoblastic and central nervous system (CNS) lymphoma] caused by loss of T-cell function, and (2) chronic B-cell hyperactivation enhancing the generation...

Topics

B-Lymphocytes
Cell Transformation, Neoplastic
Chemokine CXCL12
Chemokines, CXC
HIV Infections
Humans
Immunocompromised Host
Interleukin-6
Lymphocyte Activation
Lymphoma
Lymphoma, AIDS-Related
Phenotype
Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 12192272
DOI: 10.1097/00001622-200209000-00009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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