Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.

Breast cancer research and treatment - 1 Jan 2017

Moran Olivia, Nikitina Dina, Royer Robert, Poll Aletta, Metcalfe Kelly, Narod Steven A, Akbari Mohammad R, Kotsopoulos Joanne

Abstract excerpt

PURPOSE: BRCA mutations contribute to about 20% of all hereditary breast cancers. With full-genome sequencing as the emerging standard for genetic testing, other breast cancer susceptibility genes have been identified and may collectively contribute to up to 30% of all hereditary breast cancers. We re-assessed women who had previously tested negative for a BRCA mutation when outdated techniques were used, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Genes, BRCA1

Share to Genes, BRCA2

Share to Genetic Association Studies

Share to Genetic Predisposition to Disease

Share to Genetic Testing

Source

Identifiers

PMID: 27798748
DOI: 10.1007/s10549-016-4038-y

Genes

BRCA1
BRCA2
ATM
BLM
CHEK2
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.PMID 27798748Read ↗

Genetic testing women with newly diagnosed breast cancer: What criteria are the most predictive of a positive test?Semantic proximity Read ↗

Evaluation of Germline Genetic Testing Criteria in a Hospital-Based Series of Women With Breast Cancer.Semantic proximity Read ↗

Germline testing of BRCA1, BRCA2, PALB2 and CHEK2 c.1100delC in 1514 triple negative familial and isolated breast cancers from a single centre, with extended testing of ATM, RAD51C and RAD51D in over 400.Semantic proximity Read ↗

A study of over 35,000 women with breast cancer tested with a 25‐gene panel of hereditary cancer genesSemantic proximity Read ↗

Contribution of germline mutations in cancer predisposition genes to tumor etiology in young women diagnosed with invasive breast cancer.Semantic proximity Read ↗

Germline Mutation in 1338 BRCA-Negative Chinese Hereditary Breast and/or Ovarian Cancer Patients: Clinical Testing with a Multigene Test Panel.Semantic proximity Read ↗

Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.Semantic proximity Read ↗

Pathogenic variants among females with breast cancer and a non-breast cancer reveal opportunities for cancer interception.Semantic proximity Read ↗

Clinical Contribution of Next-Generation Sequencing Multigene Panel Testing for BRCA Negative High-Risk Patients With Breast Cancer.Semantic proximity Read ↗

Genetic Testing and Clinical Management Practices for Variants in Non-BRCA1/2 Breast (and Breast/Ovarian) Cancer Susceptibility Genes: An International Survey by the Evidence-Based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) Clinical Working GroupSemantic proximity Read ↗

Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women.Semantic proximity Read ↗

Detection of novel germline mutations for breast cancer in non-BRCA1/2 families.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.