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Article

Molecular and structural discrimination of proline racemase and hydroxyproline-2-epimerase from nosocomial and bacterial pathogens.

PloS one - 12 Sept 2007

Goytia Maira, Chamond Nathalie, Cosson Alain, Coatnoan Nicolas, Hermant Daniel, Berneman Armand, Minoprio Paola

Abstract excerpt

The first eukaryotic proline racemase (PRAC), isolated from the human Trypanosoma cruzi pathogen, is a validated therapeutic target against Chagas' disease. This essential enzyme is implicated in parasite life cycle and infectivity and its ability to trigger host B-cell nonspecific hypergammaglob...

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Source

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Identifiers

PMID: 17849014
DOI: 10.1371/journal.pone.0000885
PMCID: PMC1964878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17849014-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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