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Article

Characterization of the structure and function of Klebsiella pneumoniae allantoin racemase.

Journal of molecular biology - 15 Jul 2011

French Jarrod B, Neau David B, Ealick Steven E

Abstract excerpt

The oxidative catabolism of uric acid produces 5-hydroxyisourate (HIU), which is further degraded to (S)-allantoin by two enzymes, HIU hydrolase and 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. The intermediates of the latter two reactions, HIU and 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline, are unstable in solution and decay nonstereospecifically to allantoin. In addition, nonenzymatic...

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Identifiers

PMID: 21616082
DOI: 10.1016/j.jmb.2011.05.016
PMCID: PMC3129624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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