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SerpinE2 promotes M2 polarization in macrophage to accelerate colorectal cancer progression

20 May 2025

Abstract excerpt

Background: Cell-cell crosstalk in the tumor microenvironment (TME) is crucial for cancer development and strongly correlates with clinical outcomes. Interpatient variability in tumor microenvironment composition and function poses ongoing challenges for personalized therapy selection, remaining a significant clinical problem. Serpin family E member 2 (SERPINE2) released from the tumor microenvironment exhibits...

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PMID: 40463876
DOI: 10.3389/fonc.2025.1585935

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