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Inhibition of histone deacetylases in melanoma—a perspective from bench to bedside

28 Oct 2016

Abstract excerpt

Histone deacetylases (HDACs) are critically involved in epigenetic gene regulation through alterations of the chromatin status of DNA. Aberrant expression, dysregulation of their enzymatic activity or imbalances between HDACs and histone acetyltransferases are likely involved in the development and progression of cancer. Pharmacologic inhibition of HDACs shows potent antitumor activity in a panel of malignancies...

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PMID: 27792246
DOI: 10.1111/exd.13089

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