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Article

Expression of the class 1 histone deacetylases HDAC8 and 3 are associated with improved survival of patients with metastatic melanoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2015

Wilmott James S, Colebatch Andrew J, Kakavand Hojabr, Shang Ping, Carlino Matteo S, Thompson John F, Long Georgina V, Scolyer Richard A, Hersey Peter

Abstract excerpt

Prior studies have shown that combinations of histone deacetylase (HDAC) and BRAF inhibitors (BRAFi) have synergistic effects on BRAFi-resistant melanoma through enhanced apoptosis and inhibition of the cAMP-dependent drug resistance pathway. However, little is known about the expression of vario...

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Source

Identifiers

PMID: 25836739
DOI: 10.1038/modpathol.2015.34

Genes

BRAF
HDAC8
NRAS
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25836739-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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