Article

Role of Histone Deacetylases in Drug-Resistant Melanoma: Mechanisms and Therapeutic Implications

2025-04-08

Abstract excerpt

Melanoma remains one of the most aggressive and treatment-resistant malignancies, despite advances in targeted therapies and immunotherapies. Drug resistance continues to be a major challenge, limiting long-term therapeutic success. Epigenetic regulators, particularly histone deacetylases (HDACs), play a crucial role in melanoma progression and therapy resistance by modulating gene expression, chromatin accessibil...

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Literature Corpus work: 87457946-afc4-59f6-afdb-314e4c778db9
DOI: 10.20944/preprints202504.0662.v1

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