Article
Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations.
PloS one - 1 Jan 2016
Saigi-Morgui Núria, Quteineh Lina, Bochud Pierre-Yves, Crettol Severine, Kutalik Zoltán, Wojtowicz Agnieszka, Bibert Stéphanie, Beckmann Sonja, Mueller Nicolas J, Binet Isabelle, van Delden Christian, Steiger Jürg, Mohacsi Paul, Stirnimann Guido, Soccal Paola M, Pascual Manuel, Eap Chin B
Abstract excerpt
BACKGROUND: Polygenic obesity in Solid Organ Transplant (SOT) populations is considered a risk factor for the development of metabolic abnormalities and graft survival. Few studies to date have studied the genetics of weight gain in SOT recipients. We aimed to determine whether weighted genetic risk scores (w-GRS) integrating genetic polymorphisms from GWAS studies (SNP group#1 and SNP group#2) and from Candidate...
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