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Article

Application of human mesenchymal stem cells cultured in different oxygen concentrations for treatment of graft-versus-host disease in mice.

Biomedical research (Tokyo, Japan) - 1 Jan 2016

Kim Dae Seong, Lee Myoung Woo, Ko Young Jong, Park Hyun Jin, Park Yoo Jin, Kim Dong-Ik, Jung Hye Lim, Sung Ki Woong, Koo Hong Hoe, Yoo Keon Hee

Abstract excerpt

Human mesenchymal stem cell (MSC) heterogeneity and problems associated with the ex vivo expansion of MSC are linked with the failure of MSC clinical trials. In this study, we compared the effect of MSCs cultured in different oxygen concentrations on GVHD in mice to elucidate whether hypoxia improves the immunosuppressive capacity of MSCs. Hypoxia increased the proliferative activity and the expression of several...

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Identifiers

PMID: 27784875
DOI: 10.2220/biomedres.37.311

Genes

MSC
CCL2
CXCL10
KLF4
MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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